Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
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منابع مشابه
Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population
Background: Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA...
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Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy. Methods: KIR genes profiles were ana...
متن کاملPrevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
Background: Thyroid-associated eye disease (TED), previously known as Graves’ ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves’ disease according to sex, age and duration in northern Iran. Methods: Between April 2011 and March 2...
متن کاملEtiopathogenesis of Graves' disease.
Graves' disease is an autoimmune disorder, caused by thyroid-stimulating antibodies, which bind to and activate the thyrotropin receptor on thyroid cells, inducing the synthesis and release of thyroid hormones. It is a polygenic and multifactorial disease that develops as a result of complex interaction between genetic susceptibility and environmental and/or endogenous factors. Graves' disease ...
متن کاملManagement of thyroid ophthalmopathy: the approach and challenges
Thyroid ophthalmopathy, or Graves’ ophthalmopathy, is the most common cause of exophthalmos in adults. Graves first described thyroid disease with associated ophthalmopathy in 1835. To date, the pathogenesis of thyroid ophthalmopathy remains speculative, as reflected by the numerous names by which it is described such as dysthyroid ophthalmopathy or thyroid eye disease, thyroid orbitopathy, eut...
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